White matter signal abnormality (WMSA) is often present in the MRIs of older persons with mobility impairment. We examined the relationship between impaired mobility and the progressive accrual of WMSA. Mobility was assessed with the Short Physical Performance Battery (SPPB) and quantitative measures of gait and balance. Fourteen subjects had baseline and follow-up MRI scans performed 20Read More
Quantitative Analysis of MRI Signal Abnormalities of Brain White Matter With High Reproducibility and Accuracy
Purpose: To assess the reproducibility and accuracy compared to radiologists of three automated segmentation pipelines for quantitative magnetic resonance imaging (MRI) measurement of brain white matter signal abnormalities (WMSA). Materials and Methods: WMSA segmentation was performed on pairs of whole brain scans from 20 patients with multiple sclerosis (MS) and 10 older subjects who were positioned and imaged twice within 30Read More
The Role of Advanced MR Imaging Findings as Biomarkers of Traumatic Brain Injury
Treatment of traumatic brain injury (TBI) requires proper classification of the pathophysiology.Clinical classifiers and conventional neuroimaging are limited in TBI detection, outcome prediction, and treatment guidance. Advanced magnetic resonance imaging (MRI) techniques such as susceptibility weighted imaging, diffusion tensor imaging, and magnetic resonance spectroscopic imaging are sensitive to microhemorrhages, white matter injury, and abnormal metabolic activities, respectively, in brainRead More
Global White Matter Analysis of Diffusion Tensor Images Is Predictive of Injury Severity in Traumatic Brain Injury
Conventional clinical neuroimaging is insensitive to axonal injury in traumatic brain injury (TBI). Immunocytochemical staining reveals changes to axonal morphology within hours, suggesting potential for diffusion-weighted magnetic resonance (MR) in early diagnosis and management of TBI. Diffusion tensor imaging (DTI) characterizes the three-dimensional (3D) distribution of water diffusion, which is highly anisotropic in white matter fibers owing to axonalRead More
Acute And Chronic Changes In Diffusivity Measures After Sports Concussion.
J Neurotrauma. 2011 Oct;28(10):2049-59. Epub 2011 Oct 4. Acute and chronic changes in diffusivity measures after sports concussion. Henry LC, Tremblay J, Tremblay S, Lee A, Brun C, Lepore N, Theoret H, Ellemberg D, Lassonde M. Département de Psychology, Université de Montréal, Montréal, Québec, Canada. luke.henry@umontreal.ca Despite negative neuroimaging findingsRead More
Thalamus And Cognitive Impairment In Mild Traumatic Brain Injury: A Diffusional Kurtosis Imaging Study
J Neurotrauma. 2012 Sep;29(13):2318-27. Epub 2011 Sep 15. Thalamus and cognitive impairment in mild traumatic brain injury: a diffusional kurtosis imaging study. Grossman EJ, Ge Y, Jensen JH, Babb JS, Miles L, Reaume J, Silver JM, Grossman RI, Inglese M. 1 Center for Biomedical Imaging, Department of Radiology, New York University SchoolRead More
Multi-Modal Magnetic Resonance Imaging In The Acute And Sub-Acute Phase Of Mild Traumatic Brain Injury: Can We See The Difference?
J Neurotrauma. 2012 Aug 20. [Epub ahead of print] Multi-modal magnetic resonance imaging in the acute and sub-acute phase of mild traumatic brain injury: Can we see the difference? Toth A, Kovacs N, Perlaki G, Orsi G, Aradi M, Komaromy H, Ezer E, Bukovics P, Farkas O, Janszky J, Doczi T, Buki ARead More
143 Diffusion Tensor and Susceptibility-weighted Imaging in Concussion Assessment of National Football League Players.
Neurosurgery. 2012 Aug;71(2):E558. 143 Diffusion Tensor and Susceptibility-weighted Imaging in Concussion Assessment of National Football League Players. Luther N, Niogi S, Kutner K, Rodeo S, Shetty T, Warren R, Weiss L, Barnes R, Zimmerman R, Tsiouris A, Hartl R. INTRODUCTION: Standard magnetic resonance imaging (MRI) is normal following the vast majority ofRead More
Decreased Fractional Anisotropy Evaluated Using Tract-Based Spatial Statistics and Correlated with Cognitive Dysfunction in Patients with Mild Traumatic Brain Injury in the Chronic Stage.
AJNR Am J Neuroradiol. 2012 Jun 21. [Epub ahead of print] Decreased Fractional Anisotropy Evaluated Using Tract-Based Spatial Statistics and Correlated with Cognitive Dysfunction in Patients with Mild Traumatic Brain Injury in the Chronic Stage. Wada T, Asano Y, Shinoda J. Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital,Read More
CNS’s Research to be Presented at MRI Conference
Friday, May 18, 2012 Novi, MI (PRWEB) May 10, 2012 – The International Society for Magnetic Resonance in Medicine (ISMRM), the world’s leading society for magnetic resonance imaging (MRI) researchers and practitioners, will showcase the work of Randall Benson, MD, Medical Director of the Novi, MI-based Center for Neurological Studies during its 20th annual conference in Melbourne, Australia, thisRead More
